Ethanol → 11-Morpholinodibenzo[b,f][1,4]thiazepin-3-carboxylic Acid 5,5-Dioxide

Participants

Reaction Steps

Stir 386 mg (1 mmole) of the ester of Example 19 in a solution of 131.8 mg (2 mmole) of 85% aqueous potassium hydroxide, 1.3 ml of water, 6.5 ml of ethanol and 0.65 ml of dioxane at room temperature under argon for 1 hour. Evaporate to dryness and dissolve the residue in 5 ml of water. Acidify with acetic acid, separate the precipitate by filtration, wash with water and dry. Recrystallize from methanol to obtain the title product (m.p. 200-295 dec).

Provenance & Evidence