Tetrahydrofuran → HCID 13013940, compound

HRID 444156Notes

Reaction equation

HRID 444156 reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:13]=[C:14]([C:17]([OH:19])=[O:18])[CH:15]=[CH:16][C:4]=2[NH:3]1.O1CCC[CH2:21]1>>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:13]=[C:14]([C:17]([O:19][CH3:21])=[O:18])[CH:15]=[CH:16][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 13013939HCID 13013939, compound

Product 1

HCID 13013940HCID 13013940, compound

Procedure

Dissolve 1 gm of the acid of Example 22 with heating in 100 ml of tetrahydrofuran. Filter and cool the filtrate to room temperature. Add 500 mg. of diazomethane and stir at room temperature for 30 minutes. Strip to dryness and triturate the residue in methanol. Recover the title product by filtration. (m.p. 240°-257° C.).

Workup

  1. filtrationFilter
  2. additionAdd 500 mg
  3. customStrip to dryness and triturate the residue in methanol
  4. customRecover the title product
  5. filtrationby filtration

Sources & evidence

ORD record
ord-6b27b553b41646a29e28edd664413267
Source dataset
uspto-grants-1981_04
Patent number
US04263207

Reaction notes

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