HCID 23464483, compound → HCID 13013941, compound

Participants

Reaction Steps

Stir at room temperature 1.11 gm of the ester of Example 24 in a mixture of 50 ml of tetrahydrofuran and 50 ml of 10% aqueous sodium hydroxide for 3 hours. Separate the phases and extract the organic phase with 10% aqueous sodium hydroxide. Wash the combined aqueous phases with tetrahydrofuran and evaporate partially to remove residual tetrahydrofuran. Acidify with acetic acid. Separate the precipitate, wash with water and dry to obtain the title product (mp 352° C. dec).

Provenance & Evidence