反应详情

Stir at room temperature 1.11 gm of the ester of Example 24 in a mixture of 50 ml of tetrahydrofuran and 50 ml of 10% aqueous sodium hydroxide for 3 hours. Separate the phases and extract the organic phase with 10% aqueous sodium hydroxide. Wash the combined aqueous phases with tetrahydrofuran and evaporate partially to remove residual tetrahydrofuran. Acidify with acetic acid. Separate the precipitate, wash with water and dry to obtain the title product (mp 352° C. dec).

1. customSeparate the phases
2. extractionextract the organic phase with 10% aqueous sodium hydroxide
3. washWash the combined aqueous phases with tetrahydrofuran
4. customevaporate partially
5. customto remove residual tetrahydrofuran
6. customSeparate the precipitate
7. washwash with water
8. customdry