反应详情

Heat a mixture of 800 mg. of 3-cyano-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepine, 293 mg. of sodium azide and 265 mg. of ammonium chloride in 25 ml. of dimethylformamide at 130°-135° C. for 6 hours. Dilute the mixture with water and excess sodium carbonate. Extract with ethyl acetate. Acidify the aqueous phase and separate the precipitate by filtration to obtain the title product.

1. temperatureHeat
2. additiona mixture of 800 mg
3. extractionExtract with ethyl acetate
4. customseparate the precipitate
5. filtrationby filtration