反应详情

Compound 114 (308 mg, 1.25 mmol) was dissolved in DCM (4 mL) and the solution was cooled in an ice-water bath. TFA (3.5 mL) was then added and the mixture was stirred at room temperature for 15 min. The reaction mixture was concentrated in vacuo and the residue was dissolved in EtOAc (50 mL). The solution was washed with K2CO3 (sat., 3×), brine, dried and concentrated to yield 115 (175 mg, 95%) as a pale yellow oil. MS (APCI): m/z 147 [M+H]+.

1. temperaturethe solution was cooled in an ice-water bath
2. concentrationThe reaction mixture was concentrated in vacuo
3. dissolutionthe residue was dissolved in EtOAc (50 mL)
4. washThe solution was washed with K2CO3 (sat., 3×), brine
5. customdried
6. concentrationconcentrated