Sodium hydride → HCID 13133048, compound

HRID 444209Notes

Reaction equation

HRID 444209 reaction equation
[CH3:1][N:2]1[C:10]2[NH:11][C:12](=[O:19])[C:13]3[C:18]([C:9]=2[C:8]2[CH:7]=[C:6]([Cl:20])[CH:5]=[CH:4][C:3]1=2)=[CH:17][CH:16]=[CH:15][CH:14]=3.[H-].[Na+].[O:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH2:30]Cl)[CH2:25][CH2:24]1>>[O:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][O:19][C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:9]3[C:8]4[CH:7]=[C:6]([Cl:20])[CH:5]=[CH:4][C:3]=4[N:2]([CH3:1])[C:10]=3[N:11]=2)[CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 767274-(2-Chloroethyl)morpholineHCID 13133047HCID 13133047, compound

Product 1

HCID 13133048HCID 13133048, compound

Procedure

5-β-Morpholinoethyloxy-7-methyl-10-chloro-7H-indolo(2,3-c)isoquinoline (melting point 140°-142° C.) is prepared from 7-methyl-10-chloro-7H-indolo(2,3-c)isoquinolin-5(6H)-one, sodium hydride and β-morpholinoethyl chloride by the method described in Example 8.

Sources & evidence

ORD record
ord-d4e44409c7e64cc59cf259bcbf3733e9
Source dataset
uspto-grants-1981_04
Patent number
US04263304

Reaction notes

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