反应详情

A solution of 1-[3-(4-benzyloxycoumarin-7-yloxy)-2-hydroxypropyl]-4-(4-chlorobenzyl)piperazine (7 g) in dry DMF (80 ml) was hydrogenated at atmospheric pressure over 10% Pd/C catalyst till one equivalent of hydrogen was absorbed. Filtration and evaporation of the solvent in vacuo afforded an oily product which crystallized from ethanol/petrol to give 3.60 g (63%) of the title compound.

1. customwas absorbed
2. filtrationFiltration and evaporation of the solvent in vacuo
3. customafforded an oily product which
4. customcrystallized from ethanol/petrol