化工社化工社 化学情報印刷レポート · 研究参考用
N-bromobutanimide → 7-Bromomethyl-4-ethoxycoumarin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 4-Ethoxy-7-methylcoumarin | HCID 688944 | — |
| 反応物 | Azobisbutyronitrile | HCID 14151322 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 7-Bromomethyl-4-ethoxycoumarin | HCID 13408411 | 77% |
反応手順
N-Bromosuccinimide (9.59 g; 0.054 mole) was added to stirred solution of 4-ethoxy-7-methylcoumarin (11 g; 0.054 mole) in carbontetrachloride (600 ml) followed by a catalytic quantity of azo bisbutyronitrile. After refluxing the mixture for 1 hr the solvent was removed in vacuo and the residue recrystallized from ethanol to give 11.73 g (77%) of product of m.p. 150°-3° C. Further recrystallization gave material of m.p. 152°-155° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04263299 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-400ef893d00e4b6e843e14d73cc06316 |
| 出典メモ | uspto-grants-1981_04 |