反应详情

A suspension of 145 g. (0.433 mole) of α-bromodesoxy-p-anisoin, 88.36 g. (0.865 mole) of finely powdered 2-amino-4,5-dihydrothiazole and 179.5 g. (1.3 moles) of pulverized potassium carbonate in 1.0 liter of sieve dried acetonitrile under nitrogen was stirred at 25° C. for 3 days. The solvent was evaporated in vacuo and the residue treated with methylene chloride and 5% aqueous sodium carbonate. The organic phase was removed, washed once with 10% aqueous sodium carbonate, 3 times with water, dried over potassium carbonate, filtered and evaporated in vacuo. A solution of the residue dissolved in methylene chloride was treated with charcoal, filtered and hexane added. The precipitate was filtered and recrystallized from methylene chloride to give 5,6-bis(p-anisyl)-2,3-dihydroimidazo[2,1-b]thiazole.

1. additionA suspension of 145 g
2. customThe solvent was evaporated in vacuo
3. additionthe residue treated with methylene chloride and 5% aqueous sodium carbonate
4. customThe organic phase was removed
5. washwashed once with 10% aqueous sodium carbonate, 3 times with water
6. dry with materialdried over potassium carbonate
7. filtrationfiltered
8. customevaporated in vacuo
9. dissolutionA solution of the residue dissolved in methylene chloride
10. additionwas treated with charcoal
11. filtrationfiltered
12. additionhexane added
13. filtrationThe precipitate was filtered
14. customrecrystallized from methylene chloride