HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-Amino-6-(dimethoxymethyl)pyrazine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 3-Cyano-5-dimethoxymethyl-2-phthalimidopyrazine | HCID 13604782 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Amino-6-(dimethoxymethyl)pyrazine-2-carbonitrile | HCID 12625132 | 75.1% |
Reaction Steps
0.2 g of hydrazine hydrate were added dropwise to a suspension of 2 g of 3-cyano-5-dimethoxymethyl-2-phthalimidopyrazine in 40 ml of absolute methanol at 40° C. Immediately after the addition, the solution became clear, and crystals were precipitated after a few minutes. Chromatography over silica gel gave 0.9 g (75%) of 2-amino-3-cyano-5-dimethoxymethylpyrazine. 1H-NMR (270 MHz, DMSO-d6): δ3.3 (s, 6H), 5.0 (s, 1H), 8.35 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04725689 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-8989c551d2d14ccc86118bea21ea1108 |
| Source note | uspto-grants-1988_02 |