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HRID4443

反应详情

EQUATION

反应方程式

HRID 4443 的结构方程式

REACTANTS

反应物

2
结构：NN.O
HCID24654

Hydrazine hydrate (1:1)

H6N2O

结构：COC(OC)c1cnc(N2C(=O)c3ccccc3C2=O)c(C#N)n1
HCID13604782

未命名化合物

PRODUCTS

生成物

1
结构：COC(OC)c1cnc(N)c(C#N)n1
HCID12625132

3-Amino-6-(dimethoxymethyl)pyrazine-2-carbonitrile

C8H10N4O2

收率 75.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

0.2 g of hydrazine hydrate were added dropwise to a suspension of 2 g of 3-cyano-5-dimethoxymethyl-2-phthalimidopyrazine in 40 ml of absolute methanol at 40° C. Immediately after the addition, the solution became clear, and crystals were precipitated after a few minutes. Chromatography over silica gel gave 0.9 g (75%) of 2-amino-3-cyano-5-dimethoxymethylpyrazine. 1H-NMR (270 MHz, DMSO-d6): δ3.3 (s, 6H), 5.0 (s, 1H), 8.35 (s, 1H).

WORKUP

后处理

  1. additionImmediately after the addition
  2. customcrystals were precipitated after a few minutes