Isopropylamine → HCID 3055551, compound

HRID 444306Notes

Reaction equation

HRID 444306 reaction equation
[CH3:1][C:2]1[S:3][C:4]([CH:7]=[CH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH:17]2[O:19][CH2:18]2)=[N:5][N:6]=1.[CH:20]([NH2:23])([CH3:22])[CH3:21]>C(O)(C)C>[CH3:1][C:2]1[S:3][C:4]([CH:7]=[CH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH:17]([OH:19])[CH2:18][NH:23][CH:20]([CH3:22])[CH3:21])=[N:5][N:6]=1

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 53934759HCID 53934759, compound

Product 1

HCID 3055551HCID 3055551, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

7 g (0.025 mole) of 2-methyl-5-[2-(2,3-epoxypropoxy)-styryl]-1,3,4-thiadiazole and 2.9 g (0.05 mole) of isopropylamine are mixed in 100 ml of isopropanol and the mixture is refluxed for 7 hours. On cooling, a precipitate forms; this is recrystallized from toluene, together with the solid residue obtained from concentrating the mother liquor. 5.1 g (61% of theory), melting point 156°-157°.

Workup

  1. temperaturethe mixture is refluxed for 7 hours
  2. temperatureOn cooling
  3. customthis is recrystallized from toluene, together with the solid residue
  4. customobtained
  5. concentrationfrom concentrating the mother liquor

Sources & evidence

ORD record
ord-71791f864f4e4e64aaf1a017235f0597
Source dataset
uspto-grants-1981_04
Patent number
US04263430

Reaction notes

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