反应详情

To the suspension of phthalic anhydride (62.5 mmol) in toluene (500 ml), N,N-dimethyl hydrazine dihydrochloride (50 mmol) and diethyl-phenyl-amine (90 mmol) were added. The reaction mixture was refluxed for 18 hours while removing the formed water via a Dean-Stark trap. Then, toluene was evaporated under reduced pressure and the resulting crude was purified on silica gel chromatography with (1:5) EtOAc:dichloromethane, to give the desired product in 85% yield.

1. additionwere added
2. temperatureThe reaction mixture was refluxed for 18 hours
3. customwhile removing the formed water via a Dean-Stark trap
4. customThen, toluene was evaporated under reduced pressure
5. customthe resulting crude was purified on silica gel chromatography with (1:5) EtOAc