Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfur | HCID 5362487 | — |
| Reactant | HCID 23464966 | HCID 23464966 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | HCID 13020232 | HCID 13020232 | 75% |
Reaction Steps
A mixture of 6.93 g of α-methyl-4-cyclohexyl-3-fluorophenylacetonitrile (nD20 1.5182) and 3.46 g of sulphur in 15 ml of diphenyl ether was subjected to heating with stirring at 250° C. for 4 hours. The resulting reaction liquid was diluted with acetone, and the insoluble substances therein were removed by filtration. The filtrate was concentrated and then distilled to obtain 5.06 g of α-methyl-(2-fluoro-4-biphenylyl)acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04263457 |
|---|
| Source dataset | uspto-grants-1981_04 |
|---|
| ORD ID | ord-c7dd65461b9a48c39105a73eba1c3aa4 |
|---|
| Source note | uspto-grants-1981_04 |
|---|
