Sulfur → HCID 13020232, compound

HRID 444337Notes

Reaction equation

HRID 444337 reaction equation
[CH3:1][CH:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:7]([F:17])[CH:6]=1)[C:3]#[N:4].[S]>C1(OC2C=CC=CC=2)C=CC=CC=1.CC(C)=O>[CH3:1][CH:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([F:17])[CH:6]=1)[C:3]#[N:4]

Participants

5

Reactant 2

HCID 5362487SulfurHCID 23464966HCID 23464966, compound

Product 1

HCID 13020232HCID 13020232, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 7583Diphenyl EtherSolvent

Conditions

Temperature
250 °C

Procedure

A mixture of 6.93 g of α-methyl-4-cyclohexyl-3-fluorophenylacetonitrile (nD20 1.5182) and 3.46 g of sulphur in 15 ml of diphenyl ether was subjected to heating with stirring at 250° C. for 4 hours. The resulting reaction liquid was diluted with acetone, and the insoluble substances therein were removed by filtration. The filtrate was concentrated and then distilled to obtain 5.06 g of α-methyl-(2-fluoro-4-biphenylyl)acetonitrile.

Workup

  1. temperatureto heating
  2. customThe resulting reaction liquid
  3. customthe insoluble substances therein were removed by filtration
  4. concentrationThe filtrate was concentrated
  5. distillationdistilled

Sources & evidence

ORD record
ord-c7dd65461b9a48c39105a73eba1c3aa4
Source dataset
uspto-grants-1981_04
Patent number
US04263457

Reaction notes

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