Hydrochloric Acid → HCID 70572877, compound

Participants

Reaction Steps

3.6 g of cis-2,3-dihydro-3-[(4-methylpiperazinyl)methyl]-2-phenyl-1,5-benzothiazepin-4(5H)-one was dissolved in 10 ml of ethanol, and 2.5 ml of concentrated hydrochloric acid was added to the solution while stirring. The precipitated crystals were filtered and recrystallized from aqueous methanol to obtain cis-2,3-dihydro-3-[(4-methylpiperazinyl)methyl]-2-phenyl-1,5-benzothiazepin-4(5H)-one dihydrochloride monohydrate as colorless needles having a melting point of 212° C. (with decomposition).

Provenance & Evidence