Hydrochloric Acid → HCID 70572877, compound

HRID 444396Notes

Reaction equation

HRID 444396 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C@H:9]2[C:15](=[O:16])[NH:14][C:13]3[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=3[S:11][C@H:10]2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:4][CH2:3]1.[ClH:27]>C(O)C>[OH2:16].[ClH:27].[ClH:27].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][C@H:9]2[C:15](=[O:16])[NH:14][C:13]3[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=3[S:11][C@H:10]2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 126374HCID 126374, compound

Product 1

HCID 70572877HCID 70572877, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.6 g of cis-2,3-dihydro-3-[(4-methylpiperazinyl)methyl]-2-phenyl-1,5-benzothiazepin-4(5H)-one was dissolved in 10 ml of ethanol, and 2.5 ml of concentrated hydrochloric acid was added to the solution while stirring. The precipitated crystals were filtered and recrystallized from aqueous methanol to obtain cis-2,3-dihydro-3-[(4-methylpiperazinyl)methyl]-2-phenyl-1,5-benzothiazepin-4(5H)-one dihydrochloride monohydrate as colorless needles having a melting point of 212° C. (with decomposition).

Workup

  1. filtrationThe precipitated crystals were filtered
  2. customrecrystallized from aqueous methanol

Sources & evidence

ORD record
ord-d5c21a194f5e45eab9e7e936ed340df7
Source dataset
uspto-grants-1981_04
Patent number
US04264497

Reaction notes

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