1-Methyl-3-(piperidin-4-yl)imidazolidin-2-one → HCID 23463808, compound

HRID 444448Notes

Reaction equation

HRID 444448 reaction equation
Cl[CH2:2][CH:3]([OH:13])[CH2:4][O:5][C:6]1[C:7]([Cl:12])=[N:8][CH:9]=[CH:10][CH:11]=1.[CH3:14][N:15]1[CH2:19][CH2:18][N:17]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[C:16]1=[O:26]>C(O)(C)C>[OH:13][CH:3]([CH2:4][O:5][C:6]1[C:7]([Cl:12])=[N:8][CH:9]=[CH:10][CH:11]=1)[CH2:2][N:23]1[CH2:22][CH2:21][CH:20]([N:17]2[CH2:18][CH2:19][N:15]([CH3:14])[C:16]2=[O:26])[CH2:25][CH2:24]1

Participants

4

Reactant 2

HCID 234637981-Methyl-3-(piperidin-4-yl)imidazolidin-2-oneHCID 23463801HCID 23463801, compound

Product 1

HCID 23463808HCID 23463808, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 7.3 g of 1-chloro-3-(2-chloro-3-pyridyloxy)-2-propanol and 5.0 g of 3-methyl-1-(4-piperidyl)-imidazolidin-2-one is refluxed in 100 ml of isopropanol for 2 hours. Working up analogously to Example 1 yields oily 1-{1-[2-hydroxy-3-(2-chloro-3-pyridyloxy)-propyl]-4-piperidyl}-3-methyl-imidazolidin-2-one.

Sources & evidence

ORD record
ord-7057f4c0c61e4971928b0b1cfaddf04d
Source dataset
uspto-grants-1981_04
Patent number
US04264599

Reaction notes

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