6-(4-bromophenoxy)pyridin-3-amine → HCID 23463878, compound

HRID 444467Notes

Reaction equation

HRID 444467 reaction equation
[CH3:1][O:2][C:3]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH3:15])[C:4]=1[C:5]([N:7]=[C:8]=[O:9])=[O:6].[Br:16][C:17]1[CH:30]=[CH:29][C:20]([O:21][C:22]2[N:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=2)=[CH:19][CH:18]=1>C(OCC)(=O)C>[CH3:15][O:14][C:10]1[CH:11]=[CH:12][CH:13]=[C:3]([O:2][CH3:1])[C:4]=1[C:5]([NH:7][C:8]([NH:28][C:25]1[CH:26]=[N:27][C:22]([O:21][C:20]2[CH:29]=[CH:30][C:17]([Br:16])=[CH:18][CH:19]=2)=[CH:23][CH:24]=1)=[O:9])=[O:6]

Participants

4

Reactant 2

HCID 28001586-(4-bromophenoxy)pyridin-3-amineHCID 133219942,6-Dimethoxybenzoyl isocyanate

Product 1

HCID 23463878HCID 23463878, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2,6-Dimethoxybenzoyl isocyanate (2.0 grams) and 6-(4-bromophenoxy)-3-aminopyridine (2.3 grams) were mixed in about 50 ml. of ethyl acetate at room temperature, and the reaction mixture stirred overnight (about 17 hours) at room temperature. The product was separated by filtration and crystallized from a mixture of ethyl acetate and ethanol, yield 0.9 gram, m.p., 177°-179° C.

Workup

  1. customThe product was separated by filtration
  2. customcrystallized from a mixture of ethyl acetate and ethanol, yield 0.9 gram, m.p., 177°-179° C.

Sources & evidence

ORD record
ord-53f6202d6bfa417d88ad5c88b96b5528
Source dataset
uspto-grants-1981_04
Patent number
US04264605

Reaction notes

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