Methylamine → HCID 178484993, compound

HRID 444481Notes

Reaction equation

HRID 444481 reaction equation
[C:1]([NH:3][C:4](=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][N:13]=1)SC)#[N:2].[CH3:20][NH2:21]>C(O)C>[C:1]([NH:3][C:4]([NH:21][CH3:20])=[N:7][CH2:8][CH2:9][S:10][CH2:11][C:12]1[C:17]([O:18][CH3:19])=[CH:16][CH:15]=[CH:14][N:13]=1)#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20474175N-cyano-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]S-methylisothiourea

Product 1

HCID 178484993HCID 178484993, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-cyano-N'-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]-S-methylisothiourea (1.9 g) in ethanol (10 ml) was treated with ethanolic methylamine (20 ml 33% solution) and the resultant clear solution was allowed to stand overnight. Excess of methylamine was removed by bubbling nitrogen through the solution and the crystalline precipitate was recrystallised from ethanol to yield the title product (1.2 g), m.p. 122°-123°.

Workup

  1. customExcess of methylamine was removed
  2. customby bubbling nitrogen through the solution
  3. customthe crystalline precipitate was recrystallised from ethanol

Sources & evidence

ORD record
ord-55cc5e1433d64dbc9c392d78495abc4b
Source dataset
uspto-grants-1981_04
Patent number
US04264608

Reaction notes

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