4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid → tert-butyl 4-(4-(4-(2-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenylcarbamoyl)-2-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)phenylthio)phenylcarbamate
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C@@H:13]3[CH2:17][CH2:16][CH2:15][N:14]3[C:18](=[O:29])[C@H:19]([N:26]([CH3:28])[CH3:27])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:11][CH:12]=2)=[CH:4][CH:3]=1.[C:30]([O:34][C:35]([NH:37][C:38]1[CH:43]=[CH:42][C:41]([S:44][C:45]2[CH:53]=[CH:52][C:48]([C:49](O)=[O:50])=[CH:47][C:46]=2[NH:54][C:55]2[C:56]3[CH:64]=[CH:63][C:62]([CH:65]([CH3:67])[CH3:66])=[N:61][C:57]=3[N:58]=[CH:59][N:60]=2)=[CH:40][CH:39]=1)=[O:36])([CH3:33])([CH3:32])[CH3:31]>>[CH3:28][N:26]([CH3:27])[C@H:19]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:18]([N:14]1[CH2:15][CH2:16][CH2:17][C@H:13]1[C:10]1[NH:11][CH:12]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][C:49]([C:48]3[CH:52]=[CH:53][C:45]([S:44][C:41]4[CH:40]=[CH:39][C:38]([NH:37][C:35](=[O:36])[O:34][C:30]([CH3:33])([CH3:32])[CH3:31])=[CH:43][CH:42]=4)=[C:46]([NH:54][C:55]4[C:56]5[CH:64]=[CH:63][C:62]([CH:65]([CH3:67])[CH3:66])=[N:61][C:57]=5[N:58]=[CH:59][N:60]=4)[CH:47]=3)=[O:50])=[CH:3][CH:4]=2)[N:9]=1)=[O:29]Participants
3
Reactant 2
Product 1
Procedure
A solution of the Product of Example 2C (0.081 g, 0.21 mmol) and the product from Example 1E (0.10 g, 0.188 mmol) was processed in the same manner as in Example 1K to give a solid (0.094 g, 55%).
Sources & evidence
- ORD record
- ord-b54e1e5426c2436ea3bbb3074dd6fd98
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08541424B2
Reaction notes
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