4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid → tert-butyl 4-(4-(4-(2-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenylcarbamoyl)-2-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)phenylthio)phenylcarbamate

Participants

Role	Name	HCID	Charge
Reactant	4-(4-tert-Butoxycarbonylamino-phenylsulfanyl)-3-(7-isopropyl-pyrido[2,3-d]pyrimidin-4-ylamino)-benzoic acid	HCID 59376892	—
Reactant	HCID 178484180	HCID 178484180	—
Product	tert-butyl 4-(4-(4-(2-((S)-1-((R)-2-(dimethylamino)-2-phenylacetyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenylcarbamoyl)-2-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)phenylthio)phenylcarbamate	HCID 136158804	55.4%

Reaction Steps

A solution of the Product of Example 2C (0.081 g, 0.21 mmol) and the product from Example 1E (0.10 g, 0.188 mmol) was processed in the same manner as in Example 1K to give a solid (0.094 g, 55%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08541424B2
Source dataset	uspto-grants-2013_09
ORD ID	ord-b54e1e5426c2436ea3bbb3074dd6fd98
Source note	uspto-grants-2013_09