反应详情

The mixture of 17.7 g of ethyl α-(4-aminophenyl)-propionate, 15 g of 2-carboxy-benzaldehyde, 50 mg of p-toluenesulfonic acid and 400 ml of toluene is refluxed for two days on a water trap. After collection of the theoretical amount of water (1.9 ml), it is concentrated and the precipitate formed recrystallized from ethanol, to yield the ethyl α-[4-(3-oxo-isobenzofuran-1-ylamino)-phenyl]-propionate, melting at 136°-139°.

1. temperatureis refluxed for two days on a water trap
2. customAfter collection of the theoretical amount of water (1.9 ml), it
3. concentrationis concentrated
4. customthe precipitate formed
5. customrecrystallized from ethanol