Sodium Hydroxide → HCID 178525591, compound

HRID 444553Notes

Reaction equation

HRID 444553 reaction equation
C([O:8][C:9]([CH2:11][CH2:12][N:13]1[C:17]([SH:18])=[N:16][N:15]=[N:14]1)=[O:10])C1C=CC=CC=1.[OH-].[Na+]>O1CCCC1>[C:9]([CH2:11][CH2:12][N:13]1[C:17]([SH:18])=[N:16][N:15]=[N:14]1)([OH:10])=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178520826HCID 178520826, compound

Product 1

HCID 178525591HCID 178525591, compoundYield 75.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 3.84 g of 1-(2-benzyloxycarbonylethyl)-1H-tetrazole-5-thiol, 30 ml of tetrahydrofuran and 29 ml of 1 N-sodium hydroxide was allowed to stand at room temperature for 2 hours. The reaction mixture was washed with ethyl acetate and the water layer was adjusted to pH 1 with 10% hydrochloric acid and extracted with ethyl acetate. The extract was washed with an aqueous solution of sodium chloride, dried and concentrated to dryness. By the above procedure there were obtained 1.9 g of powder of the captioned compound.

Workup

  1. washThe reaction mixture was washed with ethyl acetate
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with an aqueous solution of sodium chloride
  4. customdried
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-2d02a35dc9c540f8955264a48157a394
Source dataset
uspto-grants-1981_04
Patent number
US04264595

Reaction notes

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