反应详情

1-(2,4,6-trichlorophenyl)-3-(2-chloro-5-tetradecanamidoanilino)-5-oxo-2-pyrazoline (21.4 g) was dissolved in 80% ethanol (ratio by volume of water:20%), and 2.42 g of anhydrous potassium carbonate was added thereto. The solution was refluxed with heating. 8.2 g of S-benzylthioisothiourea hydrochloride was added to the solution and the solution was vigorously stirred for 3 hours. After confirming the conclusion of the reaction by thin film chromatography, the reaction container was cooled with water. The formed crystals were separated by filtration and dissolved in 100 ml of hot ethanol. Insoluble materials were separated by filtration, and the filtrate was cooled. The resulting colorless crystals were Compound (1). The melting point was 182° to 185° C. and the yield was 12 g.

1. temperatureThe solution was refluxed
2. temperaturewith heating
3. customthe conclusion of the reaction by thin film chromatography
4. customThe formed crystals were separated by filtration
5. dissolutiondissolved in 100 ml of hot ethanol
6. customInsoluble materials were separated by filtration
7. temperaturethe filtrate was cooled