Trifluoroacetic acid → HCID 86653258, compound

HRID 444623Notes

Reaction equation

HRID 444623 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][C:12]([CH2:27][CH2:28][CH2:29][NH:30]C(OC(C)(C)C)=O)([CH2:16][CH2:17][CH2:18][NH:19]C(OC(C)(C)C)=O)[N+:13]([O-:15])=[O:14])=O)(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[NH2:8][CH2:9][CH2:10][CH2:11][C:12]([CH2:27][CH2:28][CH2:29][NH2:30])([CH2:16][CH2:17][CH2:18][NH2:19])[N+:13]([O-:15])=[O:14]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 11237923HCID 11237923, compound

Product 1

HCID 86653258HCID 86653258, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of tris(3-(tert-butoxycarbonylamino)propyl)nitromethane 1c (10 g, 18.8 mmol) in trifluoroacetic acid (20 ml) and dichloromethane (50 ml) was stirred at room temperature for 4 h. The reaction was then concentrated under high vacuum to afford the title compound 10c (10.8 g, 18.8 mmol. 100%) as a gum.

Workup

  1. concentrationThe reaction was then concentrated under high vacuum

Sources & evidence

ORD record
ord-cda1e91de3df47838ccda7975c2a3996
Source dataset
uspto-grants-2013_07
Patent number
US08475768B2

Reaction notes

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