HCID 67223761, compound → HCID 67224193, compound

HRID 444708Notes

Reaction equation

HRID 444708 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[N:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[N:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:8][NH:7][CH2:6]1)=[O:4]

Participants

4

Reactant 1

HCID 67223761HCID 67223761, compound

Product 1

HCID 67224193HCID 67224193, compoundYield 100.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 3-Benzyl-imidazolidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester (1.0 g, 3.12 mmol) in MeOH (20 mL) was added Pd/C (0.20 g) and stirred at room temperature under H2 for two hours. The reaction mixture was filtered through celite. The filtrate was concentrated to afford Imidazolidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester (0.72 g, xx % yield) which was used for the next step directly.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-91f298f9d8e04317b7209863e592c337
Source dataset
uspto-grants-2013_07
Patent number
US08476225B2

Reaction notes

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