1-Bromo-2-fluorobenzene → HCID 86678555, compound

HRID 444804Notes

Reaction equation

HRID 444804 reaction equation
[F:1][CH:2]([F:13])[C:3]1[CH:7]2[CH2:8][C:9]([F:12])([F:11])[CH2:10][CH:6]2[O:5][N:4]=1.Br[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[F:21]>>[F:13][CH:2]([F:1])[C:3]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[CH:7]2[CH2:8][C:9]([F:12])([F:11])[CH2:10][CH:6]2[O:5][NH:4]1

Participants

3

Reactant 2

HCID 612591-Bromo-2-fluorobenzeneHCID 71743858HCID 71743858, compound

Product 1

HCID 86678555HCID 86678555, compound

Procedure

Intermediate XXIX-1 was obtained following general procedure L: Starting from rac-(3aR,6aR)-3-difluoromethyl-5,5-difluoro-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole, the reaction with 1-bromo-2-fluoro-benzene yielded the product rac-(3S,3aR,6aR)-3-difluoromethyl-5,5-difluoro-3-(2-fluoro-phenyl)-hexahydro-cyclopenta[d]isoxazole as a light brown oil. MS: m/z=294.4 [M+H]+.

Workup

  1. customIntermediate XXIX-1 was obtained

Sources & evidence

ORD record
ord-cbfa40a3eaf349f68260620ed4b0e2de
Source dataset
uspto-grants-2013_07
Patent number
US08476264B2

Reaction notes

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