反应详情

7.9 g (30 mmol) of tert-butyl {2-[(5-cyanopyridin-2-yl)amino]ethyl}carbamate (Example 1A) were dissolved in 100 ml of 4N hydrogen chloride in dioxane and the mixture was stirred for 30 min. The reaction mixture was concentrated to half of its original volume and the same amount of diethyl ether was added. The reaction mixture was stirred for 20 min and the product was filtered off and washed with diethyl ether. This gave 7 g (94% of theory) of the product as a solid.

1. concentrationThe reaction mixture was concentrated to half of its original volume
2. additionthe same amount of diethyl ether was added
3. stirringThe reaction mixture was stirred for 20 min
4. filtrationthe product was filtered off
5. washwashed with diethyl ether