反应详情

9.5 g (23.7 mmol) of diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate (Example 10A) were dissolved in 300 ml of glacial acetic acid, and 18.3 g (237 mmol) of ammonium acetate were added. The mixture was stirred at reflux for 12 h. The reaction mixture was poured into ice-water and neutralized with sodium carbonate. The precipitate was filtered off and dried under high vacuum. This gave 6.86 g (82% of theory) of the product as a solid.

1. temperatureat reflux for 12 h
2. filtrationThe precipitate was filtered off
3. customdried under high vacuum