反应详情

2.00 g (6.3 mmol) of tert-butyl 3-[(6-amino-5-cyanopyridin-2-yl)amino]piperidine-1-carboxylate (Example 37A) were dissolved in 40 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 2 h. After the reaction had gone to completion the solvent was concentrated to half of its original volume and 20 ml of diethyl ether were added. The precipitate was filtered off and dried. This gave 1.80 g (100% of theory) of the product as a solid.

1. concentrationwas concentrated to half of its original volume and 20 ml of diethyl ether
2. additionwere added
3. filtrationThe precipitate was filtered off
4. customdried