Hydrochloric Acid → HCID 68987419, compound

HRID 444843Notes

Reaction equation

HRID 444843 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[CH:4][C:3]=1[N+:22]([O-:24])=[O:23].[ClH:25]>O1CCOCC1>[ClH:25].[N+:22]([C:3]1[C:2]([NH2:1])=[N:7][C:6]([NH:8][CH:9]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]2)=[CH:5][CH:4]=1)([O-:24])=[O:23]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57911762Tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate

Product 1

HCID 68987419HCID 68987419, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

610 mg (1.62 mmol) of tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate (Example 41A) were dissolved in 40 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 30 min. After the reaction had gone to completion, the solvent was removed completely. This gave 662 mg of the crude product.

Workup

  1. customthe solvent was removed completely

Sources & evidence

ORD record
ord-35263d2f6fb1474a810ee75f313e7ecf
Source dataset
uspto-grants-2013_07
Patent number
US08476267B2

Reaction notes

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