反应详情

80 mg (0.16 mmol) of ester (Example 3) were dissolved in 5 ml of 1,2-dimethoxyethane, and 2.5 ml of water and 0.43 ml (0.4 mmol) of 1N sodium hydroxide solution were added. The solution was stirred at RT for 2 h. 20 ml of dilute hydrochloric acid (pH 3) were initially charged, and the reaction solution was slowly added dropwise. The mixture was stirred for another 30 min, and the product was filtered off and washed with diethyl ether. This gave, after drying under high vacuum, 70 mg (84% of theory) of the product as a solid.

1. additionthe reaction solution was slowly added dropwise
2. stirringThe mixture was stirred for another 30 min
3. filtrationthe product was filtered off
4. washwashed with diethyl ether
5. dry with materialThis gave, after drying under high vacuum, 70 mg (84% of theory) of the product as a solid