Hydrochloric Acid → HCID 59293657, compound

HRID 444894Notes

Reaction equation

HRID 444894 reaction equation
[C:1]([C:5]1[N:10]=[C:9]([C:11]2[S:15][C:14]([NH:16]C(=O)C)=[N:13][C:12]=2[CH3:20])[CH:8]=[C:7]([CH3:21])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl>>[C:1]([C:5]1[N:10]=[C:9]([C:11]2[S:15][C:14]([NH2:16])=[N:13][C:12]=2[CH3:20])[CH:8]=[C:7]([CH3:21])[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59293742HCID 59293742, compound

Product 1

HCID 59293657HCID 59293657, compound

Procedure

The title compound is prepared in analogy to the procedure described in Step 1.2, but using N-[5-(2-tert-butyl-6-methyl-pyrimidin-4-yl)-4-methyl-thiazol-2-yl]-acetamide in place of N-[5-(2-tert-butyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]-acetamide and using 2 N HCl. The reaction mixture is stirred 16 h at RT and then 3 h at 90° C. ESI-MS [M+H]+263.1.

Workup

  1. custom3 h
  2. customat 90° C

Sources & evidence

ORD record
ord-5af7bb169f2649e2b9c3815e57f62125
Source dataset
uspto-grants-2013_07
Patent number
US08476268B2

Reaction notes

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