3-Amino-1,1,1-trifluoro-2-methylpropan-2-ol → 3-Amino-6-(1-methyl-1H-pyrazol-4-yl)-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide

HRID 444914Notes

Reaction equation

HRID 444914 reaction equation
[NH2:1][C:2]1[C:3]([C:18](O)=[O:19])=[N:4][C:5]([C:12]2[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=2)=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[NH2:21][CH2:22][C:23]([CH3:29])([OH:28])[C:24]([F:27])([F:26])[F:25]>>[NH2:1][C:2]1[C:3]([C:18]([NH:21][CH2:22][C:23]([OH:28])([CH3:29])[C:24]([F:27])([F:26])[F:25])=[O:19])=[N:4][C:5]([C:12]2[CH:13]=[N:14][N:15]([CH3:17])[CH:16]=2)=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:7]=1

Participants

3

Reactant 2

HCID 136207593-Amino-1,1,1-trifluoro-2-methylpropan-2-olHCID 673832773-Amino-6-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)picolinic acid

Product 1

HCID 534723863-Amino-6-(1-methyl-1H-pyrazol-4-yl)-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide

Procedure

The title compound was prepared from 3-amino-6-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoro methyl)picolinic acid and 3-amino-1,1,1-trifluoro-2-methylpropan-2-ol analogously to Example 4 1H NMR (400 MHz, Methanol-d4) δ 7.97 (1H, s), 7.85 (1H, s), 7.60 (1H, s), 3.97 (3H, s), 3.77 (1H, m), 3.56 (1H, m), 1.37 (3H, s)

Sources & evidence

ORD record
ord-45536a31d74648b59e8281aa35984fd9
Source dataset
uspto-grants-2013_07
Patent number
US08476269B2

Reaction notes

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