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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 444914Generated: October 27, 2026

3-Amino-1,1,1-trifluoro-2-methylpropan-2-ol → 3-Amino-6-(1-methyl-1H-pyrazol-4-yl)-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide

https://huagongshe.com/reaction/444914

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Amino-1,1,1-trifluoro-2-methylpropan-2-olHCID 13620759—
Reactant3-Amino-6-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoromethyl)picolinic acidHCID 67383277—
Product3-Amino-6-(1-methyl-1H-pyrazol-4-yl)-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamideHCID 53472386—

Reaction Steps

The title compound was prepared from 3-amino-6-(1-methyl-1H-pyrazol-4-yl)-5-(trifluoro methyl)picolinic acid and 3-amino-1,1,1-trifluoro-2-methylpropan-2-ol analogously to Example 4 1H NMR (400 MHz, Methanol-d4) δ 7.97 (1H, s), 7.85 (1H, s), 7.60 (1H, s), 3.97 (3H, s), 3.77 (1H, m), 3.56 (1H, m), 1.37 (3H, s)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08476269B2
Source datasetuspto-grants-2013_07
ORD IDord-45536a31d74648b59e8281aa35984fd9
Source noteuspto-grants-2013_07