1,1,1,4,4,4-Hexafluoro-2,3-butanedione → Ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate

HRID 444923Notes

Reaction equation

HRID 444923 reaction equation
[CH2:1]([O:3][C:4](=[O:10])[CH:5]([NH2:9])[C:6](=[NH:8])[NH2:7])[CH3:2].[F:11][C:12]([F:22])([F:21])[C:13](=O)[C:14](=O)[C:15]([F:18])([F:17])[F:16]>>[NH2:8][C:6]1[C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:10])=[N:9][C:14]([C:15]([F:18])([F:17])[F:16])=[C:13]([C:12]([F:22])([F:21])[F:11])[N:7]=1

Participants

3

Reactant 2

HCID 27592641,1,1,4,4,4-Hexafluoro-2,3-butanedioneHCID 12439913HCID 12439913, compound2×

Product 1

HCID 86657667Ethyl 3-amino-5,6-bis(trifluoromethyl)pyrazine-2-carboxylate

Procedure

The title compound was prepared from amino-carbamimidoyl-acetic acid ethyl ester (Intermediate B2) and 1,1,1,4,4,4-hexafluorobutane-2,3-dione analogously to Intermediate B; 10 LCMS Rt=4.72 minutes, [M+H]+ 304.2/326.1 Method 10 minLC_v002.

Sources & evidence

ORD record
ord-f5e69e152b1640d19dcd3ad827dc6d67
Source dataset
uspto-grants-2013_07
Patent number
US08476269B2

Reaction notes

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