HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[[(2,4-Diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]ethylamino]benzoyl-L-glutamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-[4-[[(2,4-Diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]methylamino]benzoyl]-L-glutamic Acid Dimethyl Ester | HCID 54044906 | — |
| Reactant | HCID 131715453 | HCID 131715453 | — |
| Product | 4-[[(2,4-Diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]ethylamino]benzoyl-L-glutamic acid | HCID 13844739 | 97% |
Reaction Steps
N-[4-[[(2,4-Diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]ethylamino]benzoyl-L-glutamic acid (21, 5-Methyl-5-deaza-10-ethylaminopterin) was prepared by saponification of 19 as described for the conversion of 18 to 20; yield 97% (56 mg from 60 mg, 0.109 mmol), of 19·0.6H2O, homogeneous by HPLC. Spectral data: mass, m/e 482 (M+1)+ ; UV, 0.1N HCl, 228 (40.8), 313 (17.1; pH 7, 227 (39.2), 308 (30.2); 0.1N NaOH, 228 (36.0), 308 (29.0).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04725687 |
| Source dataset | uspto-grants-1988_02 |
| ORD ID | ord-ec77ee8ce6d54d51817a1b5b60ea9228 |
| Source note | uspto-grants-1988_02 |