Neopentyl glycol → HCID 51341958, compound

HRID 445106Notes

Reaction equation

HRID 445106 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([B:8]([OH:10])[OH:9])=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:17])([CH2:15]O)[CH2:13]O>C1(C)C=CC=CC=1>[CH3:11][C:12]1([CH3:17])[CH2:15][O:10][B:8]([C:5]2[CH:6]=[CH:7][C:2]([OH:1])=[CH:3][CH:4]=2)[O:9][CH2:13]1

Participants

4

Reactant 2

HCID 31344Neopentyl glycolHCID 27343604-Hydroxyphenylboronic acid

Product 1

HCID 51341958HCID 51341958, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 4-hydroxyphenyl boronic acid (15.0 g) and 2,2-dimethyl-1,3-propanediol (11.4 g) in toluene (100 mL) was heated under reflux for 6 hours 30 minutes (using Dean-Stark apparatus). The resultant reaction mixture was allowed to cool and stand still and therefrom, a precipitates were filtered out and the solvent was distilled off under reduced pressure to obtain the subject compound (21.6 g) as a light gray solid.

Workup

  1. temperatureunder reflux for 6 hours 30 minutes (using Dean-Stark apparatus)
  2. customThe resultant reaction mixture
  3. temperatureto cool
  4. filtrationa precipitates were filtered out
  5. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-980afcb184dd470f865c749250b4283a
Source dataset
uspto-grants-2013_07
Patent number
US08476287B2

Reaction notes

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