反应详情

To a solution of 100 mg (0.327 mmol) (2-amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone in 1 ml dichloromethane is added 140 μl (0.818 mmol) N,N-diisopropyl-ethylamine and 48.7 μl (0.360 mmol)3-chloro-benzyl bromide. The reaction mixture is heated under reflux for 4 days and extracted with water/dichloromethane. The organic residue is chromatographed. For further purification the corresponding hydrochloride is precipitated form an etheric solution by addition of gaseous hydrochloric acid.

1. temperatureThe reaction mixture is heated
2. temperatureunder reflux for 4 days
3. extractionextracted with water/dichloromethane
4. customThe organic residue is chromatographed
5. customFor further purification the corresponding hydrochloride
6. customis precipitated form an etheric solution
7. additionby addition of gaseous hydrochloric acid