Sodium hydride → HCID 60112838, compound

Participants

Reaction Steps

11 mg (0.44 mmol) NaH is dissolved in 2 ml isopropanol and stirred for 2 h at rt. After that time 30 mg (0.088 mmol) 2-chloro-4-(4-isopropyl-phenyl)-6,7-dimethoxy-quinazoline is added and the solution is stirred at 55° C. overnight. The reaction mixture is diluted with ethyl acetate and extracted with brine. The organic layer is dried and evaporated. After chromatography (hexane/ethyl acetate) the product is obtained as yellow oil.

Provenance & Evidence