Sodium hydride → HCID 60112838, compound

HRID 445180Notes

Reaction equation

HRID 445180 reaction equation
[H-].[Na+].Cl[C:4]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][C:8]([O:25][CH3:26])=[C:9]([O:23][CH3:24])[CH:10]=2)[N:5]=1>C(O)(C)C.C(OCC)(=O)C>[CH:9]([O:23][C:4]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([CH:20]([CH3:22])[CH3:21])=[CH:16][CH:15]=2)[C:11]2[C:6](=[CH:7][C:8]([O:25][CH3:26])=[C:9]([O:23][CH3:24])[CH:10]=2)[N:5]=1)([CH3:10])[CH3:8]

Participants

5

Reactant 2

HCID 24758Sodium hydrideHCID 60112787HCID 60112787, compound

Product 1

HCID 60112838HCID 60112838, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

11 mg (0.44 mmol) NaH is dissolved in 2 ml isopropanol and stirred for 2 h at rt. After that time 30 mg (0.088 mmol) 2-chloro-4-(4-isopropyl-phenyl)-6,7-dimethoxy-quinazoline is added and the solution is stirred at 55° C. overnight. The reaction mixture is diluted with ethyl acetate and extracted with brine. The organic layer is dried and evaporated. After chromatography (hexane/ethyl acetate) the product is obtained as yellow oil.

Workup

  1. stirringthe solution is stirred at 55° C. overnight
  2. extractionextracted with brine
  3. customThe organic layer is dried
  4. customevaporated
  5. customAfter chromatography (hexane/ethyl acetate) the product is obtained as yellow oil

Sources & evidence

ORD record
ord-9c0c26bd49cb4e28a050e5ba84cc5f43
Source dataset
uspto-grants-2013_07
Patent number
US08476286B2

Reaction notes

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