HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Fluoride → HCID 60112789, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Reactant | HCID 60112787 | HCID 60112787 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 60112789 | HCID 60112789 | 33.3% |
Reaction Steps
A solution of 80 mg (0.23 mmol) 2-chloro-4-(4-isopropyl-phenyl)-6,7-dimethoxy-quinazoline and 100 mg (1.70 mmol) KF in 1 ml dimethylacetamide is stirred at 90° C. for 5 days. After extraction (ethyl acetate/brine) the organic layer is dried and evaporated. Flash-chromatography (hexane/ethyl acetate) yields 25 mg (33%) of the product as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476286B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-d1bed954e8854cf7996a03f9356e1c39 |
| Source note | uspto-grants-2013_07 |