Potassium Fluoride → HCID 60112789, compound

HRID 445182Notes

Reaction equation

HRID 445182 reaction equation
Cl[C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([O:23][CH3:24])=[C:7]([O:21][CH3:22])[CH:8]=2)[N:3]=1.[F-:25].[K+]>CC(N(C)C)=O>[F:25][C:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][C:6]([O:23][CH3:24])=[C:7]([O:21][CH3:22])[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 60112787HCID 60112787, compound

Product 1

HCID 60112789HCID 60112789, compoundYield 33.3%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

A solution of 80 mg (0.23 mmol) 2-chloro-4-(4-isopropyl-phenyl)-6,7-dimethoxy-quinazoline and 100 mg (1.70 mmol) KF in 1 ml dimethylacetamide is stirred at 90° C. for 5 days. After extraction (ethyl acetate/brine) the organic layer is dried and evaporated. Flash-chromatography (hexane/ethyl acetate) yields 25 mg (33%) of the product as yellow oil.

Workup

  1. extractionAfter extraction (ethyl acetate/brine) the organic layer
  2. customis dried
  3. customevaporated

Sources & evidence

ORD record
ord-d1bed954e8854cf7996a03f9356e1c39
Source dataset
uspto-grants-2013_07
Patent number
US08476286B2

Reaction notes

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