反应详情

Pour 1.15 g sodium metal, and 33 ml dry methanol into 100 ml four-mouth flask; add 5 g of optically active (s)-4-(6-methyloctyloxy)benzamidine hydrochloric acid salt, then pour 4.55 g of diethyl n-octylmalonate into this sodium methylate solution and then allow to react for 18 hours under heat and reflux conditions. After cooling, acidify the mixture utilizing concentrated sulfuric acid, and extract the crystals. The impure crystals are purified, and then optically active 6.32 g of (s)-5-n-octyl-2-[4-(6methyloctyloxy)phenyl]-4,6-dihydroxy-pyrimidine is obtained.

1. customto react for 18 hours
2. temperatureunder heat
3. temperaturereflux conditions
4. temperatureAfter cooling
5. extractionextract the crystals
6. customThe impure crystals are purified