HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-Methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 6-Methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate | HCID 11613376 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate hydrochloride | HCID 86655154 | — |
Reaction Steps
Add a solution of hydrogen chloride in ether (1.0 M, 5.5 mL, 5.50 mmol) to a solution of 6-methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate (2.62 g, 4.99 mmol) and dichloromethane (20 mL). Stir the mixture for 10 minutes and then concentrate to obtain the title compound (2.8 g, 4.99 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476300B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-00d2568438534ef0aee1e8942b66a26d |
| Source note | uspto-grants-2013_07 |