Hydrochloric Acid → 6-Methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate hydrochloride

HRID 445217Notes

Reaction equation

HRID 445217 reaction equation
[ClH:1].CCOCC.[F:7][C:8]([F:42])([F:41])[S:9]([O:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([O:23][CH3:24])[CH:19]=2)[C:14]=1[O:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][CH2:34][N:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)=[CH:28][CH:27]=1)(=[O:11])=[O:10]>ClCCl>[ClH:1].[F:41][C:8]([F:7])([F:42])[S:9]([O:12][C:13]1[CH:22]=[CH:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([O:23][CH3:24])[CH:19]=2)[C:14]=1[O:25][C:26]1[CH:27]=[CH:28][C:29]([O:32][CH2:33][CH2:34][N:35]2[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]2)=[CH:30][CH:31]=1)(=[O:11])=[O:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 116133766-Methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate

Product 1

HCID 866551546-Methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add a solution of hydrogen chloride in ether (1.0 M, 5.5 mL, 5.50 mmol) to a solution of 6-methoxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl trifluoromethanesulfonate (2.62 g, 4.99 mmol) and dichloromethane (20 mL). Stir the mixture for 10 minutes and then concentrate to obtain the title compound (2.8 g, 4.99 mmol).

Workup

  1. concentrationconcentrate

Sources & evidence

ORD record
ord-00d2568438534ef0aee1e8942b66a26d
Source dataset
uspto-grants-2013_07
Patent number
US08476300B2

Reaction notes

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