HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(6-Hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-(6-Hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile | HCID 58338577 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(6-Hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile hydrochloride | HCID 67308309 | — |
Reaction Steps
Add a solution of hydrogen chloride in ether (1 M, 28 μL; 28.0 μmol) to a solution of 3-(6-hydroxy-1-(4-(2-(piperidin-1-yl)ethoxy)phenoxy)naphthalen-2-yl)thiophene-2-carbonitrile (12 mg, 24.5 μmol) and dichloromethane (4 mL). Sonicate the mixture for 5 minutes and then concentrate to obtain the title compound (13 mg, 24.5 μmol). Mass spectrum (m/z): 471 (M+1-HCl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08476300B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-97ebaa5744dc4e67ae7e3a1fb27bcff7 |
| Source note | uspto-grants-2013_07 |