反应详情

To a solution of pyrimidin-5-amine (190 mg, 2.0 mmol) in pyrimidine (3 mL) was added 4-nitrophenyl chloroformate (403 mg, 2.0 mmol). The resulting mixture was stirred at RT overnight, and then heated to 60° C. overnight. After cooling to RT, the solvent was removed under vacuum to give the title compound as a brown solid, which was used in the next step without further purification. MS (ESI, positive ion) m/z: 261 (M+H).

1. temperatureheated to 60° C. overnight
2. temperatureAfter cooling to RT
3. customthe solvent was removed under vacuum